Our objective
The Olivia Hodson Cancer Fund’s objective is to provide, “Support for research and clinical advancements within the departments of Oncology, Haematology and Bone Marrow Transplant at Great Ormond Street Hospital”.
Understanding more about relapse in young patients with acute lymphoblastic leukaemia
Funds donated by OHCF will enable haematologists at GOSH use a form of DNA sequencing to help them treat and prevent relapse of a common childhood cancer.
Acute lymphoblastic leukaemia (ALL) is the most common type of cancer in children. Although treatment for it has improved and the rate of survival has progressively increased, it is an aggressive disease and many patients still relapse. The outcome from relapse is poor, therefore it is essential that we understand more about the changes that occur at this stage.
In this study, researchers will use high throughput DNA sequencing (HTS) to identify all of the genetic mutations that occur in leukaemic cells during a relapse. As a result, they hope to be able to provide important information on the prevention and treatment of relapse in childhood ALL.
OHCF funds will constitute a ‘pump priming’ grant for this project, paying for the consumables required to deliver a small-scale proof of principle over a 12-month period. The GOSH team plan to publish the results of their new research in medical journals or present them internationally, before applying for further grants to conduct wider studies with a larger patient group.
Projects
Research into drug repositioning for treatment of rare brain tumours
Acute Myeloid Leukaemia (AML) is a heterogeneous blood cancer that accounts for 15-20% of all paediatric acute leukaemia cases. Despite it's low incidence in children, it is a life-threatening …Identification of novel surface antigen targets for CAR T cell strategies in paediatric Acute Myeloid Leukaemia stem cells
Acute Myeloid Leukaemia (AML) is a heterogeneous blood cancer that accounts for 15-20% of all paediatric acute leukaemia cases. Despite it's low incidence in children, it is a life-threatening …
Reducing Stress and empowering children undergoing operations with the use of Lip balms on breathing masks.
It has been found that by providing children with a choice of flavoured lip balms to put onto their breathing masks before undergoing operations is beneficial in many ways.
Toward drug repurposing in epigenetics: Targeting histone modifications as a novel approach for a selective treatment for DIPG.
Diffuse intrinsic pontine glioma (DIPG) is a very aggressive tumour that mostly affect young children and is the main cause of brain tumour death in children. Mutations that cause …
Identifying the needs of childhood cancer survivors as they approach adulthood
An OHCF-funded study will help healthcare professionals at GOSH understand the ongoing needs of children who have survived cancer, thereby improving the care they receive as they enter adolescence.
Characterising novel therapeutic targets for neuroblastoma
OHCF is supporting significant research into potential new therapies for this very serious form of childhood cancer.
Delivering rapid and efficient genetic screening for bone marrow failure syndromes
A new, more efficient method of DNA sequencing will help ICH scientists quickly identify causes of bone marrow failure syndromes.
Understanding more about relapse in young patients with acute lymphoblastic leukaemia
Funds donated by OHCF will enable haematologists at GOSH use a form of DNA sequencing to help them treat and prevent relapse of a common childhood cancer.
Evaluating expanded tumour infiltrating lymphocytes (TILs) in children’s solid cancers
A pilot study by the Institute for Child Health aims to understand how a treatment that has generated a response in some adult cancer patients might also have a …