The Olivia Hodson Cancer Fund’s objective is to provide, “Support for research and clinical advancements within the departments of Oncology, Haematology and Bone Marrow Transplant at Great Ormond Street Hospital”.
Toward drug repurposing in epigenetics: Targeting histone modifications as a novel approach for a selective treatment for DIPG.
Diffuse intrinsic pontine glioma (DIPG) is a very aggressive tumour that mostly affect young children and is the main cause of brain tumour death in children. Mutations that cause epigenetic alterations have recently been highlighted as the major driver for this tumour. The key goals of this project are to establish whether targeting the epigenome of DIPGs with a drug already clinically approved can be a novel approach to reverse the progression of this tumour.